https://ogma.newcastle.edu.au/vital/access/ /manager/Index en-au 5 Variation in cardiovascular disease risk factors among older adults in the Hunter Community Study cohort: A comparison of diet quality versus polygenic risk score https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50122 Tue 11 Jul 2023 15:09:52 AEST ]]> Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47202 Thu 15 Dec 2022 11:18:18 AEDT ]]> The role of polygenic risk score gene-set analysis in the context of the omnigenic model of schizophrenia https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:42338 N = 29,125 cases and 34,836 controls), a robust polygenic signal was observed from gene sets based on TCF4, FMR1, upregulation from MIR137 and downregulation from CHD8. Additional analyses revealed a constant floor effect in the amount of variance explained, consistent with the omnigenic model. Thus, we report that putative core gene sets showed a significant effect above and beyond the floor effect that might be linked with the underlying omnigenic background. In addition, we demonstrate a method to quantify the contribution of specific gene sets within the omnigenic context.]]> Mon 22 Aug 2022 14:00:20 AEST ]]> Human Genetics Society of Australasia Position Statement: Use of Polygenic Scores in Clinical Practice and Population Health https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51355 Fri 01 Sep 2023 13:43:26 AEST ]]>